Lion’s Mane
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- Made in USA
- Third-party tested
- Method : Advanced Extraction with Sound Waves
Commonly known as the “Smart Mushroom”, Lion’s Mane (Hericium erinaceus) has been traditionally used to combat brain fog, boost mental clarity, and promote overall nervous system health. If you ever walk into a room and forget why you’ve gone in there, this mushroom is for you! Lion’s Mane has strong neurotrophic and neuroprotective capabilities, making it the ideal choice for improving your nervous system. This mushroom produces unique bioactive compounds, hericenones and erinacines (both named after its scientific name), that give Lion’s Mane its strong stimulatory effects. One of the mechanisms by which Lion’s Mane promotes enhanced nervous system function is through improved gut microbiome health, which in turn has positive impacts on brain performance. Please check out the references below regarding cutting-edge research on Lion’s Mane and improved cognitive function, gastrointestinal disorders, microbiota diversity, neurodegenerative diseases, heart health, and more!‡
‡These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Recommended Use
Place 1-3 full droppers of tincture into your beverage of choice, or if you’re on the go, you can pop it right under your tongue.
Servings
Our 2 oz bottles contain up to 60 servings!
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A Note on Quality
Not all mushroom extracts are created equal. Across the mushroom tincture industry there is a common practice to utilize extract ratios to “justify” potency without actually testing the concentration of desirable compounds. For example, a company may claim their tincture is potent due to using an extract ratio of 5:1, which indicates they use 5kg of raw materials to create 1kg of mushroom extract. But what if their extraction methods are just…inefficient? How does that company know that a 5:1 ratio yields a “potent” content of the desired compounds? How can these companies tell that their growing conditions and extraction methods are yielding a tincture that is high in these unique compounds? Other companies that claim “third-party tested” may also only test for polysaccharide content (i.e., beta glucans). Although alpha-beta glucans have many beneficial properties, functional mushrooms are typically grown because they have very unique compounds that are only produced by that particular mushroom, such as Ganodermic acid by Reishi. Even more so, companies may use myceliated grains and not fruiting bodies, which can skew the “polysaccharide content” in their tinctures since polysaccharides are founds in grains. Some companies may only do water-based extraction, which does not yield a “full spectrum” extract since certain compounds produced by mushrooms are more soluble in alcohols. At Gulf Spore we know our extracts are potent because we have done the work…we optimized our growing conditions, enhanced our extraction techniques, and performed rigorous lab tests for compounds other than beta-glucans! We use green chemistry methods and ultrasonication, or sound waves, to break open the tough cell walls of mushrooms and more efficiently access the unique compounds to deliver the purest and most potent mushroom tinctures on the market. We also grow our mushrooms from spore to harvest, using only organic and non-GMO substrate. In other words, we don’t cut corners so that we can extract the full potential of mushrooms!
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BIOACTIVES
- Hericenones: Hericenone C, D, and E
- Hericene A
- Ergosterol
- β-glucans
- Chitin
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RESEARCH AND REFERENCES
Maša Černelič Bizjak, Zala Jenko Pražnikar, Saša Kenig, Matjaž Hladnik, Dunja Bandelj, Andrej Gregori, Katja Kranjc, Effect of erinacine A-enriched Hericium erinaceus supplementation on cognition: A randomized, double-blind, placebo-controlled pilot study, Journal of Functional Foods, Volume 115, 2024, 106120, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2024.106120.
Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
He, X., Wang, X., Fang, J., Chang, Y., Ning, N., Guo, H., ... & Zhao, Z. (2017). Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion’s Mane) mushroom: A review. International journal of biological macromolecules, 97, 228-237.
Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
Gravina AG, Pellegrino R, Auletta S, Palladino G, Brandimarte G, D'Onofrio R, Arboretto G, Imperio G, Ventura A, Cipullo M, Romano M, Federico A. Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases. World J Gastroenterol. 2023 May 28;29(20):3048-3065. doi: 10.3748/wjg.v29.i20.3048. PMID: 37346156; PMCID: PMC10280799.
Li, TJ., Lee, TY., Lo, Y. et al. Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo. BMC Complement Med Ther 21, 295 (2021). https://doi.org/10.1186/s12906-021-03463-3.
Nagano M., Shimizu K., Kondo R., Hayashi C., Sato D., Kitagawa K., Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed. Res. 2010;31:231–237. doi: 10.2220/biomedres.31.231.
Docherty S, Doughty FL, Smith EF. The Acute and Chronic Effects of Lion's Mane Mushroom Supplementation on Cognitive Function, Stress and Mood in Young Adults: A Double-Blind, Parallel Groups, Pilot Study. Nutrients. 2023 Nov 20;15(22):4842. doi: 10.3390/nu15224842. PMID: 38004235; PMCID: PMC10675414.
Chong, P.S., Poon, C.H., Roy, J. et al. Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression. Chin Med 16, 132 (2021). https://doi.org/10.1186/s13020-021-00546-8.
Vigna, Luisella, Morelli, Federica, Agnelli, Gianna M., Napolitano, Filomena, Ratto, Daniela, Occhinegro, Alessandra, Di Iorio, Carmine, Savino, Elena, Girometta, Carolina, Brandalise, Federico, Rossi, Paola, Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers?, Evidence-Based Complementary and Alternative Medicine, 2019, 7861297, 12 pages, 2019. https://doi.org/10.1155/2019/7861297.
Sun Ryu, Hyoun Geun Kim, Joo Youn Kim, Seong Yun Kim, and Kyung-Ok Cho. Hericium erinaceus Extract Reduces Anxiety and Depressive Behaviors by Promoting Hippocampal Neurogenesis in the Adult Mouse Brain. Journal of Medicinal Food 2018 21:2, 174-180. https://doi.org/10.1089/jmf.2017.4006.
Gençalp Rüstem, Duygu, Aydin, Hikmet Hakan, Kalmis, Erbil, Kayalar, Husniye and Ak, Handan. The effects of Hericium erinaceus extracts on cell viability and telomerase activity in MCF-7 cells. Turkish Journal of Biochemistry, vol. 48, no. 3, 2023, pp. 298-302. https://doi.org/10.1515/tjb-2022-0170.
Atay, Sevcan & Ak, Handan & Kalmis, Erbil & Kayalar, Husniye & Aydin, Hikmet. (2020). Transcriptome Wide Analysis Reveals the Molecular Mechanism of Tumoricidal Effects of Lion’s Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes) on MCF-7 Breast Cancer Cells. International Journal of Medicinal Mushrooms. 23. 10.1615/IntJMedMushrooms.2020037448.
Rahman MA, Abdullah N, Aminudin N. Inhibitory effect on in vitro LDL oxidation and HMG Co-A reductase activity of the liquid-liquid partitioned fractions of Hericium erinaceus (Bull.) Persoon (lion's mane mushroom). Biomed Res Int. 2014;2014:828149. doi: 10.1155/2014/828149. Epub 2014 May 13. PMID: 24959591; PMCID: PMC4052699.
Huang, HT., Ho, CH., Sung, HY. et al. Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein. Sci Rep 11, 6551 (2021). https://doi.org/10.1038/s41598-021-85972-2.
Yanshree, Wing Shan Yu, Man Lung Fung, Chi Wai Lee, Lee Wei Lim, and Kah Hui Wong. 2022. The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells 11, no. 15: 2284. https://doi.org/10.3390/cells11152284.
Bell, V., Ferrão, J., Chaquisse, E., Manuel, B., & Fernandes, T. (2019). Role of mushrooms in autism. Austin J. Nutri. Food Sci, 7(6), 1128.
Wong, K. H., Naidu, M., David, R. P., Bakar, R., & Sabaratnam, V. (2012). Neuroregenerative potential of lion's mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers.(higher Basidiomycetes), in the treatment of peripheral nerve injury. International journal of medicinal mushrooms, 14(5). -
Cautions
As always, consult your physician before consuming, especially if you are pregnant or taking other medications. Do not consume if you are allergic to mushrooms. Keep out of reach of children. Store in a cool place.
100% fruiting bodies
